1980-1989

Tangnu, S.K., C.R. Wilke and H.W. Blanch, “Production of Xylanase by Streptomyces xylophagus”, Acta Biotechnol. 1, 31 (1981).

  Tangnu, S.K., H.W. Blanch and C.R. Wilke, “Enhanced Production of Cellulase, Hemicellulase and beta-glucosidase by Trichoderma reesei (RutC30)”, Biotechnol. Bioeng. 23, 1837 (1981).

  McBride, C., J. Walter, H.W. Blanch, and T.W.F. Russell, “Bubble Coalescence Breakup in Fermentations,” Proc. 4th  International Fermentation Symposium. 1 (78), 489 (1981).

  Michaels, S.L. and H.W. Blanch, “Ethanol Production from non-Grain Feedstocks,”, Acta Biotechnologica 1,(4) 351 (1981).

  Blanch, Harvey W., Invited Review.  "Microbial Growth Kinetics."  Chemical Eng. Commun. 8, 181-211 (1981).

  Blanch, Harvey W., Planning for Renewable Resources - Biomass. Proceedings of Chem. Tech. International Congress, Bombay, India, 5, 1 (1981).

  Rosenberg, S.L., T.R. Batter, H.W. Blanch and C.R. Wilke,"Hemicellulose Utilization for Ethanol Production," AIChE Symp. Series, Chemicals from Wood (1981).

  Maiorella, B., C.R. Wilke, H.W. Blanch, "Alcohol Production and Recovery"  Advances in Biochemical Engineering, vol 20, Bioenergy, ed. A. Fiechter, Springer Verlag (1981).

  MooYoung, M. and H.W. Blanch"Design of Biochemical Reactors Mass Transfer for Criteria for Simple and Complex Systems,"  Adv. Biochem. Eng. 19,, 2 (1981).

  Maiorella, B., C.R. Wilke and H.W. Blanch "Alcohol Production and Recovery,"  AIChE Symp. Series, Chemicals from Wood. (1981).

  Blanch, H.W. and C.R. Wilke, Sugars and Chemicals from Cellulose, Reviews in Chemical Engineering, eds., N.E. Amundson and D. Luss, vol 1, 1 (1982).

  Vick Roy, Bruce, C.R. Wilke and H.W. Blanch, Lactic Acid Production by Lactobacillus delbreuckii in a Hollow Fiber Fermenter, Biotechnology Letters, 4(8) 483 (1982).

  Blanch, H.W., A. Kaufman, and A.S. Michaels, Advances in Fermentation Recovery Process Technology, First Engineering Conference, Alberta, Canada, 712 June, 1981. Publ. in Enzyme Microb. Technology 4 284 (1982).

  Murphy, T.K., H.W. Blanch and C.R. Wilke "Water Recycle in Extractive Fermentation," Process Biochemistry 17 (6) 6, NovemberDecember (1982).

  Maiorella, B., H.W. Blanch and C.R. Wilke, ByProduct Inhibition Effects on Ethanolic Fermentation by Saccharomyces cerevisiae, Biotechnol. Bioeng. Symp. Series, Biotechnol. Bioeng. 25, 103121 (1982)

  Hendy, N., C.R. Wilke and H.W. Blanch,  "Enhanced Cellulase Production Using Solka Floc in a Fed Batch Fermentation, Biotechnology Letters, 4 (12) 785-788 (1982).

  Walter, J.F. and H.W. Blanch, "Liquid Circulation Patterns and Their Effect on Gas HoldUp and Axial Mixing in Bubble Columns," Chem. Eng. Communications 19, 243262 (1983).

  Hao, J.O., M.G. Richard, D. Jenkins, and H.W. Blanch, The Half Saturation Coefficient for Dissolved Oxygen:  A Dynamic Method for Its Determination and Its Effect on Dual Species Competition," Biotechnol. Bioeng., 25, 403416 (1983).

  Blanch, H.W. and C.R. Wilke, "Cellulase Production of Kinetics," Proc. Canadian Royal Society Symp. on Ethanol from Biomass (1983).

  Blanch, H.W. "Biotechnology: doing well in the lab but struggling in the plant," Ind. Research and Development, p. 76, August 1983.

  Vick Roy, T.B., M. Mandel, D.K. Dea, H.W. Blanch, C.R. Wilke, "The Application of Cell Recycle to Continuous Fermentative Lactic Acid Production,." Biotechnology Letters, 5, 665 (1983).

  MooYoung, M., H.W. Blanch,"Reactor Design" American Chemical Society Symp.Series, No. 207, eds. Blanch H.W., Papoutsakis, E.T. and G. Stephanopoulos "Foundations of Biochemical Engineering", 336354 (1983).

  Antonopolis, R.A., H.W. Blanch, R.P. Freitas, A.F. Sciamanna, C.R. Wilke, "Production of Sugars from Wood using High Pressure Hydrogen Chloride" Biotechnol. Bioeng. 25, 2757 (1983)

  Maiorella, B.L., H.W. Blanch, C.R. Wilke,  "Distillery Effluent Treatment and ByProduct Recovery"  Process Biochemistry 18, 5 (1983).

  Vick Roy, T.B., H.W. Blanch, C.R. Wilke, "Microbial  Hollow Fiber Bioreactors,"  Trends in Biotechnology, 1 (5), 135, (1983).

  Blanch, Harvey W., "Cell Growth and Enzyme Kinetics," Biotech Advs 1, 193204, (1983).

  MooYoung, M. and H.W. Blanch,  Kinetics and Transport Phenomena in Biological Reactor Design,  ACS Symp. Ser., 207, 33554 (1983).

  Hendy, N.A., C.R. Wilke, and H.W. Blanch, "Enhanced Cellulase Production in Fed Batch Culture of Trichoderma reesei C30," Enzyme and Microbial Technology 6, 73 (1984).

  Blanch, H.W., "Engineering Challenges of Genetic Engineering,"  Biotechnol. Bioeng. Symp. No. 13, 1984, p467.

  Wald, Stephen, Charles R. Wilke and Harvey W. Blanch,  "Kinetics of the Enzymatic Hydrolysis of Cellulose," Biotechnol. Bioeng. 26, 221230 (1984).

  Blanch, H. W., "Immobilized Microbial Cells, Annual Reports on Fermentation Processes, 7, 1984.

  Maiorella, B.L., Wilke, C.R., Blanch, H.W. , "Ethanol Volatility in Fermentation Systems. Salt and Metabolite Effects", I&EC Fundamentals 23, 332 (1984).

  Maiorella, B.L., Blanch, H.W., Wilke, C.R. , "Economic Evaluation of Alternative Ethanol Fermentation Processes" Biotechnol. Bioeng. 26, 10031025 (1984).

  Maiorella, B.L., Blanch, H.W., Wilke, C.R., "Feed Component Inhibition in Ethanolic Fermentation by S. cerevisiae"  Biotechnol. Bioeng. 26, 1155-1166 (1984).

  Castillo, F.J., Blanch, H.W., Wilke, C.R. "Lactase Production in Continuous Culture by Trichoderma reesei (Rut C30)", Biotechnology Letters 6(9) 593 (1984).

  Roffler, S.R., Blanch, H.W., Wilke, C.R.,  "In Situ Recovery of Fermentation Products," Trends in Biotechnology, September/October 1984, 2(5), pp. 12936.

  Blanch, Harvey W., Vick Roy, T. Bruce, Wilke, Charles R.,  "Growth of Procaryotic Cells in Hollow Fibre Reactors,  Enzyme Engineering, 7, 373, Ann. N.Y. Acad. Sci 434, (1984). 

  H.W. Blanch, F.H. Arnold, and C.R. Wilke,  "Mass Transfer Effects in Affinity Chromatography", 3rd European Congress on Biotechnology, Vol. 1, Munchen, Federal Republic of Germany, 1014 September 1984.

  Arnold, F.H., Chalmers, J.J. Saunders, M.S. Croughan, H.W. Blanch, C.R. Wilke, "A Rational Approach to the ScaleUp of Affinity Chromatography," ACS Symp. Series 271, 123 (1985).

  Arnold, F.H., H.W. Blanch, and C.R. Wilke,  "Liquid Chromatography  Plate Heights Equations," J. of Chromatography 330 (1985) 159166. Elsevier Science Publishers, Netherlands

  Randolph, T.W., H.W. Blanch, J.M. Prausnitz, and C.R. Wilke , "Enzymatic Catalysis in a Supercritical Fluid", Biotechnol. Lett. 7(5), 325328 (1985).

  Arnold, F.H., H.W. Blanch and C.R. Wilke,  "Analysis of Affinity Separations I. Predicting the Performance of Affinity Adsorbers", The Chemical Engineering J. 30, B923 (1985).

  Arnold, F.H., H.W. Blanch and C.R. Wilke, "Analysis of Affinity Separations.  II. The Characterization of Affinity Columns by Pulse Techniques", The Chemical Engineering J.l 30, B25B36 (1985).

  Ohleyer, Eric, Harvey W. Blanch and Charles R. Wilke, Review, Continuous Production of Lactic Acid in a Cell Recycle Reactor, Applied Biochemistry and Biotechnology, 11, 317331 (1985). Humana Press, Inc. 

  Ohleyer, Eric, Charles R. Wilke and Harvey W. Blanch, "Continuous Production of Lactic Acid from Glucose and Lactose in a Cell Recycle Reactor," Applied Biochemistry and Biotechnology, The Humana Press, Inc., 11 457463 (1985).

  Walter, James F. and Harvey W. Blanch, "Bubble Breakup in GasLiquid Bioreactors:  Breakup in Turbulent Flows", The Chemical Engineering J. 32 B7B17 (1986).

  Oolman, T.O. and  Blanch, H.W., "Bubble Coalescence in Stagnant Liquids." Chemical Engineering Communications 43 237261 (1986).

  Oolman, T.O. and  H.W. Blanch, "Bubble Coalescence in Air Sparged Reactors", Biotechnol. Bioeng. 28 (4), 578 (1986).

  San Martin, R., H.W. Blanch, C.R. Wilke, and A.F. Sciamanna,  "Production of Cellulase Enzymes and Hydrolysis of SteamExploded Wood," Biotechnol. Bioeng. 28 (4), 564 (1986).

  Arnold, F.H., S.A. Schofield, and H.W. Blanch, "Analytical Affinity Chromatography, I.  Local Equilibrium Theory and the Measurement of Association and Inhibition Constants", J. of Chromatography, 335 (1), 112 (1986).

  Arnold, F.H. and H.W. Blanch, "Analytical Affinity Chromatography,  II. Rate Theory and the Measurement of Biological Binding Kinetics", J. of Chromatography 335 (1), 1327 (1986).

  Oolman, T.O. and  Blanch, H.W., "NonNewtonian Fermentation Systems," Critical Review in Biotechnology 4 (2) 133184 (1986).  CRC Press.

  Miller, William M., Andy A. Lin, Charles R. Wilke and Harvey W.Blanch, "Polymer Biocompatibility  Effect on Hybridoma Growth and Metabolism", Biotechnology Letters 8 (7), 463468 (1986).

  Blanch, Harvey W., Stephen Drew, and Daniel I.C. Wang, Comprehensive Biotechnology, Volume Editors, "The Practice of Biotechnology:  Current Commodity Products, (l986).  

  Drapeau, Denis, Yves Sauvaire, Harvey W.Blanch and Charles R. Wilke, "Improvement of Diosegenin Yield from Dioscorea deltoidea Plant Cell Cultures by Use of a NonTraditional Hydrolysis Method," Planta Medica, Thieme, Inc., New York, N.Y. (December 6, 1986).

  Roffler, S.R., H.W. Blanch and C.R. Wilke, "In situ Recovery of Butanol during Fermentation, Part I:  Batch Extractive Fermentation", Bioprocess Engineering 2, 1l2. (1987). 

  MooYoung, M., H.W. Blanch, "Transport Phenomena and Bioreactor Design," Basic Biotechnology, Ed. Bu'Lock and Christersen, Academic Press, Fla. March, 1987. 

  Roffler, S.R., H.W. Blanch and C.R. Wilke,"In situ Recovery of Butanol During Fermentation, Part 2:  Fed Batch Extractive Fermentation", Bioprocess Engineering 2 (1987) 181-190.

  Furlong, Clement E., Joseph A. Sundstrom and R.J. Richeter, John Yin and Harvey W. Blanch, "Removal of Phosphate and Other Small Molecules from Waste streams Binding Proteins in Cycling Column Adsorbers",  Environmental biotechnology: reducing risks from environmental chemicals”, eds. Gilbert S. Omenn, Rita R. Colwell (1987)

  Drapeau, Denis, H.W. Blanch and C.R. Wilke, "Growth Kinetics of   Dioscorea deltoidea and Cathranthus roseus in Batch Culture. Biotechnol. and Bioeng. 28, 1555 (1986). 

  Drapeau, Denis, Harvey W.Blanch and Charles R. Wilke, "Liquid Chromatographic Isolation of Vincristine and Vinblastine," J. of Chromatography, 390 (2) 297 (1987).

  Miller, William M., Charles R. Wilke, and Harvey W. Blanch, "Effects of Dissolved Oxygen Concentration on Hybridoma Growth and Metabolism in  Continuous Culture,"  J. of Cellular Physiology 132 524-530 (1987).

  Drapeau, Denis, Harvey W. Blanch and Charles R. Wilke, "Ajamalicine, Serpentine, and Catharanthine Accumulation in Catharanthus roseus Bioreactor Cultures, Planta Medica, 53 (4), 373-376 (1987). 

  Drapeau, D., H.W. Blanch and C.R. Wilke,"Economic Assessment of Plant Cell Culture for Production of Ajmallicine, Biotech. & Bioeng., 30 946-953 (1987).

  Roffler, Steven, Harvey W. Blanch and Charles R. Wilke, "Extractive Fermentation of Acetone and Butanol:  Process Design and Economic Evaluation," Biotechnology Progress, 3(3), 131 (1987).

  Eggers, D.K and H.W. Blanch,"Enzymatic Production of L-Tryptophane in Liquid Membrane Systems," Bioprocess Engineering  3, 2330 (1988).

  Eggers, D.K. and H.W. Blanch, "Enzymatic Production of L-tryptophan in a Reverse Micelle Reactor, Bioprocess Engineering, 3, 8391 (1988).

  Roffler, S.R., H.W. Blanch and C.R. Wilke, "In Situ Extractive Fermentation of Acetone and Butanol", Biotechnol. Bioeng. 31, l35-l43 (1988).

  Randolph, T.W., D.S. Clark, H.W.Blanch and J.M. Prausnitz, "Enzymatic Oxidation of Cholesterol Aggregates in Supercritical Carbon Dioxide," Science 239, 387-390, January 22, 1988. 

  Randolph, Theodore and Harvey W. Blanch, "Cholesterol Aggregation and Interaction with Cholesterol Oxidase in Supercritical CO2, Proc. Nat'l Acad. Sci., USA., Vol. 85, pp.29792983, May, 1988.

  Miller, W.M., C.R. Wilke and H.W. Blanch, "Transient responses of hybridoma metabolism to changes in the oxygen supply rate in continuous culture, Bioprocess Engineering 3, 103111 (1988). Springer Verlag.

  Miller, William, C.R.Wilke and H.W. Blanch, Transient response of hybridoma cells to lactate and ammonia pulse and step changes in continuous culture, Bioprocess Engineering 3, 113122 (1988)  Springer Verlag.

  Randolph, T.W., H.W. Blanch, and J.M. Prausnitz, "EnzymeCatalyzed Oxidation of Cholesterol in Supercritical Carbon Dioxide, AIChE J. 34(8),  13541360, 1988

  King, R.S., Blanch, H.W. and J.M. Prausnitz, "Molecular Thermodynamics of Aqueous Two-Phase Systems for Bioseparations ",  AIChE Journal 34 1585-1594 (1988) 

  Roffler, Stephen R., Charles R. Wilke, and Harvey W. Blanch, "Design and Mathematical Description of Differential Contactors Used in Extractive Fermentations, Biotechnology and Bioengineering, 32, 192-204 (1988).  

  Furlong, C.E., Sundstrom, J.A., Yin, J., Blanch, H.W., Robinson, N.J., Lindsay, W.P. and P.J. Jackson, " Heavy Metal Bioadsorption", Proceedings Eur. Conf. Biotechnology, Verona, p1, Nov. (1988)

  Miller, W.M., H.W. Blanch and C.R. Wilke, "A Kinetic Analysis of Hybridoma Growth and Metabolism in Batch and Continuous Suspension Culture:  Effect of nutrient concentration, dilution rate and pH", Biotechnol. Bioeng. 32, (8), 947 (1988)

  Furlong, Clement E., Joseph A. Sundstrom, Edward B. Weiler, Peter W. Cheung, John Yin and Harvey W. Blanch, "Exploitation of the High Affinity and Specificity of Proteins in Waste Stream Treatment", Basic Life Sciences 45, 27180 (1988).

  Clark, Douglas S., Paul S. Skerker, Ted W. Randolph, Harvey W.Blanch, and John M. Prausnitz, "Conformational Analyses of Enzymes and Substrates in Processing Environments", Enzyme Engineering, 542, 16, Annals of the New York Academy of Sciences, December 1, 1988. 

  Blanch, H.W., D.L. Eggers, R.A. Ramelmeier, L. Creagh, D.S. Clark, and J.M. Prausnitz, "Enzyme Bioreactors Employing Reverse Micelles and Two Phase Systems" Presented at the 8th Int'l Biotechnology Symp., Paris, July 1722, 1988, Edited by Durand G. Bobichon, L.Florent, J. Societe Francaise de Microbiologie. Vols. 1, 577 (1988). 

  Ramelmeier, R.A. and H.W. Blanch, "Peroxidase Catalyzed Oxidation of p Anisidine with H2O2 Toluene" Biotechnol. Bioeng. 33, 512517 (1989). 

  Miller, W.M., C.R. Wilke and H.W. Blanch, "The Transient Responses of Hybridoma Cells to Nutrient Additions in Continuous Culture: I. Glucose Pulse and Step Changes, "Biotechnol. Bioeng. 33, 477486 (1989)    

  Miller, W.M., C.R. Wilke and H.W.Blanch, "The Transient Responses of Hybridoma Cells to Nutrient Additions in Continuous Culture: II. Glutamine Pulse and Step Changes, Biotechnol. Bioeng. 33, 487499 (1989).

  Eggers, Daryl K., Harvey W. Blanch and John M. Prausnitz, "Extractive catalysis:  solvent effects on equilibria of enzymatic reactions in twophase systems, Enzyme Microb. Technol. 33, 11, (l989).  

  Clark, Douglas S., Louise Creagh, Paul Skerker, Mark Guinn, John Prausnitz, and Harvey W. Blanch, "Enzyme Structure and Function in Water Restricted Environments", ACS Symp. Series 392, Eds:  James D. Burrington and Douglas S. Clark, 1989.

  Ramelmeier, R.A. and H. W. Blanch, " Mass Transfer and Cholesterol Oxidase Kinetics in a LiquidLiquid TwoPhase System", Biocatalysis, 2, 97120 (1989).

  Yin, John and Harvey W. Blanch, "A BioMimetic Cadmium Adsorbent:  Design, Synthesis and Characterization", Biotechnol. Bioeng. 34, 180188 (1989).

  C.A. Haynes, R.A. Beynon, R.S. King, H.W. Blanch, and J.M. Prausnitz, "Thermodynamic Properties of Aqueous Polymer Solutions:  Poly(ethylene glycol)/Dextran", The Journal of Physical Chemistry,  93, 5612 (1989).

  Thomas, Susan N., Harvey W. Blanch, and David S. Soane, "A Novel Optical Method for the Measurement of Biomolecular Diffusion in Polymer Matrices", Biotechnology Progress, 5, (3) 126, (1989) 

  Pina, C. Clark, D.S. and H.W. Blanch, "The Activity of PEGmodified Chymotrypsin in Aqueous and Organic Media", Biotech. Techniques, 3, (5) (1989)

  Blanch, H.W., "Introduction to Bioreactor Engineering" in Bioprocessing and Food Process Engineering, chap 2., p19, eds. H. Schwartzburg, A. Rao, Marcel Dekker (1989).

  C.A. Haynes, H.W. Blanch and J.M. Prausnitz,"Separation of Protein Mixtures by Extraction:  Thermodynamic Properties of Aqueous TwoPhase Polymer Systems Containing Salts and Proteins, J. Fluid Phase Equilib. 53, 463 (1989)

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