2010-present

Detmer Sipkema, Harvey W. Blanch, “Spatial distribution of bacteria associated with the marine sponge Tethya californiana”, Marine Biology, 157, 627-638 (2010)

 Wendorf, J., Radke, C.J. & H.W. Blanch, “The role of electrolytes in protein adsorption at the solid water interface”, Colloids and Surfaces. B: Biointerfaces, 75, 100-106 (2010)

  Timothy C.R. Brennan, Supratim Datta, Harvey W. Blanch, Blake A. Simmons, Bradley M. Holmes, “Recovery of Sugars from Ionic Liquid Biomass Liquor by Solvent Extraction”, Bioenergy Research, 3, 123-133 (2010)

  Supratim Datta, Bradley Holmes, Joshua I Park, Zhiwei Chen, Dean C. Dibble, Masood Hadie, Harvey Blanch, Blake Simmons, and Rajat Sapra, “Ionic liquid tolerant hypothermophilic cellulases for biomass pretreatment and hydrolysis”, Green Chemistry, 12, 338-345 (2010)  

 Cong T. Trinh, Sarah Huffer, Melinda E. Clark, Harvey W. Blanch, Douglas S. Clark. “Elucidating Mechanisms of Solvent Toxicity in Ethanologenic Escherichia coli”,  Biotechnology & Bioengineering, 106, 721-730 (2010)

 Blake A. Simmons, Seema Singh, Bradley M. Holmes, and Harvey W. Blanch, “Ionic Liquids as Effective Biomass Solvents: Scientific Curiosity or Commercially Viable Biofuel Pretreatment Technology?”, Chemical Engineering Progress,  50-55, March  (2010)

 Blanch., H.W., “Extraction chemistry of fermentation product carboxylic acids”, Biotechnology & Bioengineering, 103, 431 (2010) 

 Seth E. Levine, Jerome M. Fox, Harvey W. Blanch, Douglas S. Clark, “A mechanistic model of the enzymatic hydrolysis of cellulose”, Biotechnology & Bioengineering, 107, 37-51 (2010)

 Tae-Wan Kim, Harshal A. Chokhawala, Dana Nadler, Harvey W. Blanch, Douglas S. Clark, “Binding modules alter the activity of chimeric cellulases: Effects of biomass pretreatment and enzyme source”, Biotechnology & Bioengineering, 107, 601-611 (2010)

 Klein-Marcuschammer, D., Simmons, B., Blanch, H.W., “Technoeconomic Analysis Of Biofuels: A Wiki-Based Platform For Lignocellulosic Biorefineries”, Biomass & Bioenergy, 34, 1912-1921 (2010)  

   Sasisankar Padmanabhan, Paul Wolski, Kierston Shill, Douglas Clark, Harvey Blanch, “Ionic Liquid Pretreatment of Cellulosic Biomass: Enzymatic Hydrolysis and Ionic Liquid Recycle”, Biotechnology & Bioengineering, 108, 511-520 (2010)

 Detmer Sipkema, Klaske Schippers, Wouter J. Maalcke, Yu Yang, Sina Salim and Harvey W. Blanch, “Multiple approaches to enhance the cultivation of bacteria associated with the marine sponge Haliclona(?) gellius”,  Applied & Environmental Microbiology,  77 (6), 2130-2140  (2011)

 Klein-Marcuschammer, D., Simmons, B., Blanch, H.W., “Biofuel Economics”, Chapter 14, p321-346, Advances in Biochemical Engineering and Biotechnology, Plant Biomass Conversion, eds. Hood, E.E., Nelson, P., and Powell, R. Wiley-Blackwell (2011)

 Trinh, C.T., Li, J., Blanch, H.W., Clark, D.S., “Redesigning E. coli metabolism for anaerobic production of isobutanol”, Appl. Env. Microbiol., 77 (14), 4894-4904 (2011)

 Prausnitz, John; Fendt, Sebastian; Padmanabhan, Sasisanker; Blanch, Harvey, “Viscosities of Acetate or Chloride Based Ionic Liquids and Some of their Mixtures with Water or Other Common Solvents", J. Chem. & Eng. Data, 56 (1), 31-34  (2011)

 Graham, J.E., Clark, M., Nadler, D., Huffer, S., Chokhawala, H.A., Rowland, S., Blanch, H.W., Clark, D.S., Robb, F., “Identification and characterization of a multidomain hyperthermophilic cellulase from an archaeal enrichment”, Nature Communications, 2, Article 375 (2011)

 Huffer, S., Clark, M., Ning, J., Blanch, H.W., Clark, D.S., “The Role of Alcohols in Growth, Lipid Composition, and Membrane Fluidity of Yeast, Bacteria, and Archaea”, Appl. Env. Microbiol., 77 (18) 6400-6408 (2011)

 Klein-Marcuschammer, D., Simmons, B., Blanch, H.W., “Techno-economic analysis of a lignocellulosic ethanol biorefinery with ionic liquid pre-treatment”, Biofuels, Bioproducts & Biorefining, 5, 562-569 (2011)

 Blanch, H.W., Klein-Marcuschamer, D., Simmons, B.A., “Biomass Deconstruction to Sugars”, Biotechnology Journal, 6, 1086-1102 (2011)

 Padmanabhan, S., Kim, M., Blanch, H.W., Prausnitz, J.M., “Solubility and Rate of Dissolution for Miscanthus in Hydrophilic Ionic Liquids”, Fluid Phase Equilibria, 309 (1), 89-96 (2011)

 Kim, T-W, Chokhawala, H., Hess, M., Dana, C., Baer, Z., Sczyrba, A., Rubin, E., Blanch, H.W., Clark, D.S., “High-throughput in vitro Glycoside Hydrolase (HIGH) Screening for Enzyme Discovery”, Angewandte Chemie, 123 (47), 11411-11414  (2011) [Featured on Cover]

 Levine, S., Fox, J.M., Clark, D.S., Blanch, H.W., “A mechanistic model for rational design of optimal cellulase mixtures”, Biotech. Bioeng., 108 (11), 2561-2570 (2011)

 Blanch, H.W., “Bioprocessing for Biofuels”, Current Opinion in Biotechnology 23(3), 390-395 (2011)

 Huffer, S., Clark, M., Ning, J., Blanch, H., Clark, D., “Role of Alcohols in Growth, Lipid Composition, and Membrane Fluidity of Yeasts, Bacteria, and Archaea”, Appl. Env. Microbiol.,  77 (18), 6400-6408 (2011)

 Shill, K., Padmanabhan, S., Xin, S., Prausnitz, J.M., Clark, D.S., Blanch, H.W., “Ionic liquid pretreatment of cellulosic biomass: Enzymatic hydrolysis and ionic liquid recycle”, Biotechnol. Bioeng.  108 (3), 511-520 (2011)

 Padmanabhan, S., Kim, M., Blanch, H.W/, Prausnitz, J.M., “Solubility and rate of dissolution for Miscanthus in hydrophilic ionic liquids”, Fluid Phase Equilibria, 309 (1), 89-96 (2011)

 Wolski, P., Clark, D.S., Blanch, H.W.,  “Green fluorescent protein as a screen for enzymatic activity in ionic liquid–aqueous systems for in situ hydrolysis of lignocellulose”, Green Chem.,  13, 3107-3110 (2011)

 Sasisanker Padmanabhan, Edmond Zaia, Katherine Wu, Harvey W. Blanch, Douglas S.Clark, Alexis T. Bell, and John M. Prausnitz, “Delignification of Miscanthus by Extraction”, Separation Science and Technology,  47 (2), 370-376 (2011)

 Klein-Marcuschammer, D., Oleskowicz-Popiel, P., Simmons, B., Blanch, H.W, “The challenge of enzyme cost in the production of lignocellulosic biofuels”, Biotech. Bioeng. 109 (4) 1083-1087 (2012)

 Xin, S.,  Pfeiffer, K. Prausnitz, J.M., Clark, D.S., Blanch, H.W., “Extraction of lignins from aqueous–ionic liquid mixtures by organic solvents”, Biotechnol. Bioeng. 109 (2), 346-352 (2012)

 Fox, J.M., Levine, S.E., Blanch, H.W., Clark, D.S., “An evaluation of cellulose saccharification and fermentation with an engineered Saccharomyces cerevisiae capable of cellulose and xylose utilization”, Biotechnology Journal, 7 (3), 361-373 (2012)

 Zhiwei Chen, Gregory D. Friedland, Jose H. Pereiraa,c, Sonia A. Revecoa,c, Rosa Chand, Joshua I. Parka, Michael P. Thelena, Paul D. Adams, Adam P. Arkin, Jay D. Keasling, Harvey W. Blanch, Blake A. Simmons, Kenneth L. Sale, Dylan Chivian and Swapnil R. Chhabra, “Tracing determinants of dual-substrate specificity in glycoside hydrolase family 5”, J. Biol. Chemistry, 287, 25335-25343  (2012)

 Fox, J.M., Levine, S.E., Clark, D.S., Blanch, H.W., “Initial- and Processive-Cut Products Reveal Cellobiohydrolase Rate Limitations and the Role of Companion Enzymes”, Biochemistry, 51, 422-452 (2012)

 Oleskowicz-Popiel, P., Kadar, Z., Heiske, S., Klein-Marcuschamer, D., Simmons, B. A., Blanch, H. W. and Schmidt, J. E. (2012). "Co-production of ethanol, biogas, protein fodder and natural fertilizer in organic farming--evaluation of a concept for a farm-scale biorefinery." Bioresource Technol, 104 (2012): 440-446

 Dana, C.M., Saija, P., Kal, S.M., Bryan, M., Blanch, H.W., Clark, D.S., “Biased clique shuffling reveals stabilizing mutations in cellulase Cel7A”, Biotech. Bioeng. 109 (11) 2710-2719 (2012)

 Huffer, S., Roche, C.M., Blanch, H.W., Clark, D.S., “Escherichia coli for biofuel production: bridging the gap from promise to practice”, Trends in Biotechnology, 30 (10) 538-545 (2012)

 Anbarasan, P., Baer, Z.C., Sreekumar, S., Binder, J., Blanch, H.W., Clark, D.S., Toste, F.D., “Integration of chemical catalysis with extractive fermentation to produce fungible fuels”, Nature 491, 235-239, November 8th, (2012) 

 Shill, K., Miller, .K., Clark, D.S., Blanch, H.W., “A model for optimizing the enzymatic hydrolysis of ionic liquid pretreated lignocellulose”, Bioresource Technology, 126, 290-297 (2012)

 Blanch, HW, “Ask the Experts: the food versus fuel debate”, Biofuels 3(6) 635-648 (2012)

 Piotr Oleskowicz-Popiel, Daniel Klein-Marcuschamer, Blake Simmons and Harvey Blanch, “Technoeconomic analysis of lignocellulosic ethanol production through ionic liquid pretreatment, acid hydrolysis, and sugar extraction”, Biotechnology for Biofuels, (to appear  2013)

 Jan-Georg Rosenboom; Daniel Klein-Marcuschamer, Harvey W Blanch, “Technoeconomic analysis of a lignocellulosic ethanol biorefinery with ozonolysis pretreatment”, Biomass and Bioenergy (submitted 2012)

 Jerome M. Fox, Phillip Jess, Rakesh B. Jambusaria, Genny M. Moo, Jan Liphardt, Douglas S. Clark, and Harvey W. Blanch, “A quantitative single-molecule analysis reveals morphological targets for cellulase synergy”, Nature Chem Bio, 9 356-361 (2013)

Christine M. Roche, Harvey W. Blanch, Douglas S. Clark, N. Louise Glass, “Physiological role of acyl-CoA synthetase homologs in lipid metabolism in Neurospora crassa”, Eukaryotic Cell, doi: 10.1128/EC.00079-13 (2013)

Klein-Marcuschamer, D., Blanch, H.W., “Survival of the fittest: An economic perspective on the production of novel biofuels”, AIChE Journal, 59(12), 445 4-4460 (2013)

Piotr Oleskowicz-Popiel, Daniel Klein-Marcuschamer, Blake Simmons and Harvey Blanch, “Lignocellulosic ethanol production without enzymes - technoeconomic analysis of ionic liquid pretreatment followed by acidolysis”, Bioresource Technology, 158, 294-299 (2014)

Dana, C., Dotson-Fagerstrom, A., Roche, C., Kal, S.M., Chokhawala, H.A., Blanch, H.W., Clark, D.S., “ The Importance of Pyroglutamate in Cellulase Cel7A”, Biotech. Bioeng, 111 (4), 842-847 (2014)

Noppadon Sathitsuksanoh, Kevin Holtman, Daniel J Yelle, Trevor J Morgan, Vitalie Stavila, Jeffrey Pelton, Harvey W. Blanch, Blake A. Simmons and Anthe George, “Lignin fate and characterization during ionic liquid biomass pretreatment for renewable chemicals and fuels production”, Green Chemistry, 16 (3), 1236-1247 (2014)

Christine M. Roche, N. Louise Glass, Harvey W. Blanch, Douglas S. Clark, “Engineering the filamentous fungus Neurospora crassa for lipid production from lignocellulosic biomass”, Biotech. Bioeng. 111(6) 1097-1107 (2014)

Konda, NVSNM, Shi, J., Singh, S., Blanch, HW, Simmons, BA, Klein-Marcuschamer, D, “Understanding cost drivers and economic potential of two variants of ionic liquid pretreatment for cellulosic biofuel production”, Biotechnology for Biofuels,  7:86 (2014)

Frederix, M., Hutter, K., Leu, J., Batth, T., Turner, W., Ruegg, T., Blanch, HW, Simmons, BA, Adams, PA, Keasling, J., Thelen, M, Dunlop, M, Petzold, C, Mukhopadhyay, A., “Development of a native E. coli induction system for ionic liquid tolerance”, PLOS One, June 14, 9(7), 2014

Sebastian Bormann, Zachary C. Baer, Sanil Sreekumar, Jon M. Kuchenreuther, F. Dean Toste, Harvey W. Blanch, Douglas S. Clark, “Engineering Clostridium acetobutylicum for production of kerosene and diesel blendstock precursors”, Metabolic Engineering, 25 124-130 (2014)

Sanil Sreekumar, Zachary C Baer, Anbarasan Pazhamalai, Gorkem Gunbas, Adam Grippo, Harvey W Blanch, Douglas S Clark and F Dean Toste, “Production of an acetone- butanol- ethanol mixture from Clostridium acetobutylicum and its conversion to high-value biofuels”, Nature Protocols, 10, 528-537 (2015)

Klein-Marchuschamer, D., Blanch, H.W., “Renewable fuels from biomass: Technical hurdles and economic assessment of biological routes”, AIChE Journal, 61(9) 2689-2701 (2015)

Chokhawala, H., Roche, CM, Kim, TW, Atreya, ME,  Vegesna, N., Dana, CM, Blanch, HW, Clark, DS, “Mutagenesis of Trichoderma reesei endoglucanase I: impact of expression host on activity and stability at elevated temperatures”, BMC Biotechnology 2015, 15:11 

Kathryn L. Strobel, Katherine A. Pfeiffer, Harvey W. Blanch and Douglas S. Clark, “Structural insights into the affinity of Cel7A carbohydrate-binding module for lignin”, Journal of Biological Chemistry, 290, 22818-22826 (2015)

Katherine A. Pfeiffer, Hagit Sorek, Christine M. Roche, Kathryn L. Strobel, Harvey W. Blanch and Douglas S. Clark, “Evaluating endoglucanase Cel7B-lignin interaction mechanisms and kinetics using quartz crystal microgravimetry”, Biotech. Bioeng., 112(11), 2256-2266 (2015)

Kathryn L. Strobel, Katherine A. Pfeiffer, Harvey W. Blanch and Douglas S. Clark, “Engineering Cel7A carbohydrate binding module and linker for reduced lignin inhibition”, Biotech. Bioeng.,  10.1002/bit.25889 December (2015)

Wolski, P., Dana, C.M., Clark, D.S., Blanch, H.W. “Engineering ionic liquid-tolerant cellulases for biofuels production”, Protein Engineering Design and Selection, 29 (2), (2016)

Zachary C. Baer, Sebastian Bormann, Sanil Sreekumar, Adam Grippo, F. Dean Toste, Harvey W. Blanch & Douglas S. Clark, “Co-production of acetone and ethanol with molar ratio control enables production of improved gasoline or jet fuel blends”, Biotech. Bioeng. Biotech. Bioeng. 113 (10) 2079-2087 (2016)

Wheeldon, I., Christopher, P., Blanch, H.W., “Integration of heterogeneous and biochemical catalysis for production of fuels and chemicals from biomass”, Current Opinion in Biotechnology, 45 127-135 (2017)


© Harvey Blanch 2013